Cardioprotective efficiency of postconditioning using L-lactate during ischemia-reperfusion of myocardium in young and old rats under conditions of the systemic action in the animal body of the blocker of M-cholinoreactive systems atropine

Myocardial protection from ischemic and reperfusion injury is an important task of modern experimental clinical medicine. This type damage a key link in the pathogenesis coronary heart disease and, above all, acute myocardial infarction – socio-economically significant that one main causes disability mortality adult population Republic Belarus. The aim study was to elucidate cardioprotective efficiency postconditioning (Post) using L-lactate during ischemia–reperfusion myocardium young old rats under conditions systemic action body animals blocker M-cholinergic systems atropine. In experiments on rats, it found Post has infarct-limiting effect both animals, however, atropine (2 mg/kg), this partially preserved only rats. Apparently, activity peripheral mechanisms implementation effects young, but not